Chlamydia muridarum T-Cell Antigens Formulated with the Adjuvant DDA/TDB Induce Immunity against Infection That Correlates with a High Frequency of Gamma Interferon (IFN-γ)/Tumor Necrosis Factor Alpha and IFN-γ/Interleukin-17 Double-Positive CD4(+) T Cells

Major impediments to developing a Chlamydia vaccine lie in identifying immunologically relevant T-cell antigens and delivery in a manner to stimulate protective immunity. Using an immunoproteomic approach, we previously identified three immunodominant Chlamydia T-cell antigens (PmpG-1, PmpE/F-2, and...

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Bibliographic Details
Main Authors: Yu, Hong, Jiang, Xiaozhou, Shen, Caixia, Karunakaran, Karuna P., Jiang, Janina, Rosin, Nicole L., Brunham, Robert C.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Microbial Immunity and Vaccines
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863536/
https://ncbi.nlm.nih.gov/pubmed/20231405
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.01374-09
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