Synergic Effect of Genotype Changes in Pertussis Toxin and Pertactin on Adaptation to an Acellular Pertussis Vaccine in the Murine Intranasal Challenge Model

The Bordetella pertussis pertussis toxin and pertactin (Prn) are protective antigens and are contained in acellular pertussis vaccines. Polymorphisms in the A subunit of pertussis toxin (PtxA) and pertactin have been proposed to mediate vaccine resistance and contribute to pertussis reemergence. To...

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Bibliographic Details
Main Authors: Komatsu, Eiji, Yamaguchi, Fuminori, Abe, Akio, Weiss, Alison A., Watanabe, Mineo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Vaccine Research
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863393/
https://ncbi.nlm.nih.gov/pubmed/20357056
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/CVI.00449-09
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