Mechanistic Insight into the Function of the C-terminal PKD Domain of the Collagenolytic Serine Protease Deseasin MCP-01 from Deep Sea Pseudoalteromonas sp. SM9913: BINDING OF THE PKD DOMAIN TO COLLAGEN RESULTS IN COLLAGEN SWELLING BUT DOES NOT UNWIND THE COLLAGEN TRIPLE HELIX

Deseasin MCP-01 is a bacterial collagenolytic serine protease. Its catalytic domain alone can degrade collagen, and its C-terminal PKD domain is a collagen-binding domain (CBD) that can improve the collagenolytic efficiency of the catalytic domain by an unknown mechanism. Here, scanning electron mic...

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Detalhes bibliográficos
Main Authors: Wang, Yu-Kai, Zhao, Guo-Yan, Li, Yang, Chen, Xiu-Lan, Xie, Bin-Bin, Su, Hai-Nan, Lv, Yao-Hui, He, Hai-Lun, Liu, Hong, Hu, Jun, Zhou, Bai-Cheng, Zhang, Yu-Zhong
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Enzymology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2863174/
https://ncbi.nlm.nih.gov/pubmed/20207733
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.087023
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