The inhibition of apoptosis by melatonin in VSC4.1 motoneurons exposed to oxidative stress, glutamate excitotoxicity, or TNF-α toxicity involves membrane melatonin receptors

Loss of motoneurons may underlie some of the deficits in motor function associated with CNS injuries and diseases. We tested whether melatonin, a potent antioxidant and free radical scavenger, would prevent motoneuron apoptosis following exposure to toxins and whether this neuroprotection is mediate...

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Bibliografiske detaljer
Main Authors: Das, Arabinda, McDowell, Misty, Pava, Matthew J, Smith, Joshua A., Reiter, Russel J., Woodward, John J., Varma, Abhay K., Ray, Swapan K., Banik, Naren L.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862889/
https://ncbi.nlm.nih.gov/pubmed/20082663
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-079X.2009.00739.x
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