Conformational rearrangements of SV40 large-T antigen during early replication events

SV40 large tumor antigen (LTag) functions as the replicative helicase and initiator for viral DNA replication. For SV40 replication, the first essential step is the assembly of LTag double hexamer at the origin DNA that will subsequently melt the origin DNA to initiate fork unwinding. Here we use th...

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Main Authors: Cuesta, Isabel, Núñez-Ramírez, Rafael, Scheres, Sjors H. W., Gai, Dahai, Chen, Xiaojiang S., Fanning, Ellen, Carazo, Jose María
格式: Artigo
語言:Inglês
出版: 2010
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862297/
https://ncbi.nlm.nih.gov/pubmed/20219473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jmb.2010.02.042
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