Variants in ADCY5 and near CCNL1 are associated with fetal growth and birth weight

To identify genetic variants associated with birth weight, we meta-analyzed six genome-wide association (GWA) studies (N=10,623 Europeans from pregnancy/birth cohorts) and followed up two lead signals in thirteen replication studies (N=27,591). Rs900400 near LEKR1 and CCNL1 (P=2×10(−35)), and rs9883...

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Hlavní autoři: Freathy, Rachel M, Mook-Kanamori, Dennis O, Sovio, Ulla, Prokopenko, Inga, Timpson, Nicholas J, Berry, Diane J, Warrington, Nicole M, Widen, Elisabeth, Hottenga, Jouke Jan, Kaakinen, Marika, Lange, Leslie A, Bradfield, Jonathan P, Kerkhof, Marjan, Marsh, Julie A, Mägi, Reedik, Chen, Chih-Mei, Lyon, Helen N, Kirin, Mirna, Adair, Linda S, Aulchenko, Yurii S, Bennett, Amanda J, Borja, Judith B, Bouatia-Naji, Nabila, Charoen, Pimphen, Coin, Lachlan J M, Cousminer, Diana L, de Geus, Eco J. C., Deloukas, Panos, Elliott, Paul, Evans, David M, Froguel, Philippe, Glaser, Beate, Groves, Christopher J, Hartikainen, Anna-Liisa, Hassanali, Neelam, Hirschhorn, Joel N, Hofman, Albert, Holly, Jeff M P, Hyppönen, Elina, Kanoni, Stavroula, Knight, Bridget A, Laitinen, Jaana, Lindgren, Cecilia M, McArdle, Wendy L, O'Reilly, Paul F, Pennell, Craig E, Postma, Dirkje S, Pouta, Anneli, Ramasamy, Adaikalavan, Rayner, Nigel W, Ring, Susan M, Rivadeneira, Fernando, Shields, Beverley M, Strachan, David P, Surakka, Ida, Taanila, Anja, Tiesler, Carla, Uitterlinden, Andre G, van Duijn, Cornelia M, Wijga, Alet H, Willemsen, Gonneke, Zhang, Haitao, Zhao, Jianhua, Wilson, James F, Steegers, Eric A P, Hattersley, Andrew T, Eriksson, Johan G, Peltonen, Leena, Mohlke, Karen L, Grant, Struan F A, Hakonarson, Hakon, Koppelman, Gerard H, Dedoussis, George V, Heinrich, Joachim, Gillman, Matthew W, Palmer, Lyle J, Frayling, Timothy M, Boomsma, Dorret I, Smith, George Davey, Power, Chris, Jaddoe, Vincent W V, Jarvelin, Marjo-Riitta, McCarthy, Mark I
Médium: Artigo
Jazyk:Inglês
Vydáno: 2010
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862164/
https://ncbi.nlm.nih.gov/pubmed/20372150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/ng.567
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