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Arsenite Causes Down-Regulation of Akt and c-Fos, Cell Cycle Dysfunction and Apoptosis in Glutathione-Deficient Cells
Arsenic is a well known environmental toxicant but the mechanism by which it causes cytotoxicity is poorly understood. Arsenite induces apoptosis in glutathione (GSH)-deficient GCS-2 cells by causing cell cycle dysfunction and down-regulating critical signaling pathways. This study was designed to e...
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2862122/ https://ncbi.nlm.nih.gov/pubmed/20336670 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcb.22548 |
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