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The Adjuvant CLDC Increases Protection of a Herpes Simplex Type 2 Glycoprotein D Vaccine in Guinea Pigs

Herpes simplex virus (HSV) infections are common but there is no vaccine available. We evaluated cationic liposome-DNA complexes (CLDC) as an adjuvant for an HSV gD2 vaccine and compared it to an MPL/Alum adjuvant in a guinea pig model of genital herpes. The addition of CLDC to the gD2 vaccine signi...

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Detalhes bibliográficos
Main Authors: Bernstein, David I, Farley, Nicholas, Bravo, Fernando J., Earwood, Julie, McNeal, Monica, Fairman, Jeff, Cardin, Rhonda
Formato: Artigo
Idioma:Inglês
Publicado em: 2009
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2862079/
https://ncbi.nlm.nih.gov/pubmed/19857450
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.vaccine.2009.10.025
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