The Connectivity Map links Iron Response Protein-1 (IRP1)-mediated inhibition of HIF2a translation to the anti-inflammatory 15-deoxy-Δ(12,14)-Prostaglandin J(2)

Hypoxia Inducible Factors 1 and 2 (HIF1 and HIF2) are heterodimeric transcription factors consisting of alpha regulatory subunits and a constitutively expressed beta subunit. The expression of alpha regulatory subunits is promoted by hypoxia, cancer-associated mutations and inflammatory cytokines. T...

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Main Authors: Zimmer, Michael, Lamb, Justin, Ebert, Benjamin L., Lynch, Mary, Neil, Christopher, Schmidt, Emmett, Golub, Todd R., Iliopoulos, Othon
Formato: Artigo
Idioma:Inglês
Publicado: 2010
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861799/
https://ncbi.nlm.nih.gov/pubmed/20354189
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-2877
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