Absence of insulin signalling in skeletal muscle is associated with reduced muscle mass and function: evidence for decreased protein synthesis and not increased degradation

Loss of skeletal muscle mass and function is observed in many insulin-resistant disease states such as diabetes, cancer cachexia, renal failure and ageing although the mechanisms for this remain unclear. We hypothesised that impaired insulin signalling results in reduced muscle mass and function and...

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Hauptverfasser: O’Neill, Elaine D., Wilding, John P. H., Kahn, C. Ronald, Van Remmen, Holly, McArdle, Anne, Jackson, Malcolm J., Close, Graeme L.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Springer Netherlands 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861753/
https://ncbi.nlm.nih.gov/pubmed/20431988
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s11357-009-9125-0
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