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Effect of renal lipid accumulation on proximal tubule Na(+)/H(+) exchange and ammonium secretion

Patients with metabolic syndrome have increased risk of uric acid nephrolithiasis due to lower urinary pH and impaired ammonium excretion. The pathophysiology underlying these urinary changes is unknown. We used two animal models and a cell culture model to study whether the alteration in renal acid...

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Main Authors: Bobulescu, I. Alexandru, Dubree, Michele, Zhang, Jianning, McLeroy, Paul, Moe, Orson W.
格式: Artigo
語言:Inglês
出版: 2008
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861570/
https://ncbi.nlm.nih.gov/pubmed/18417539
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00550.2007
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