Five Years of Large-Scale dhfr and dhps Mutation Surveillance Following the Phased Implementation of Artesunate Plus Sulfadoxine-Pyrimethamine in Maputo Province, Southern Mozambique

Accumulation of mutations in dihydrofolate reductase (dhfr) and dihydropteroate synthetase (dhps) is strongly associated with sulfadoxine-pyrimethamine (SP) treatment failure. Routine surveillance for these resistance markers was conducted annually at 26 sentinel sites in Maputo Province, Mozambique...

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Main Authors: Raman, Jaishree, Little, Francesca, Roper, Cally, Kleinschmidt, Immo, Cassam, Yasmin, Maharaj, Rajendra, Barnes, Karen I.
Format: Artigo
Language:Inglês
Published: The American Society of Tropical Medicine and Hygiene 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861376/
https://ncbi.nlm.nih.gov/pubmed/20439956
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.4269/ajtmh.2010.09-0401
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