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Blocking hedgehog signaling after ablation of the dorsal neural tube allows regeneration of the cardiac neural crest and rescue of outflow tract septation

Cardiac neural crest cells (CNCC) migrate into the caudal pharynx and arterial pole of the heart to form the outflow septum. Ablation of the CNCC results in arterial pole malalignment and failure of outflow septation, resulting in a common trunk overriding the right ventricle. Unlike preotic cranial...

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Autori principali: Hutson, Mary Redmond, Sackey, Faustina N., Lunney, Katherine, Kirby, Margaret L.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2861338/
https://ncbi.nlm.nih.gov/pubmed/19765571
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2009.09.013
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