NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway

Nucleotide-binding oligomerization domain 1 (NOD1) is an intracellular epithelial cell protein known to play a role in host defense at mucosal surfaces. Here we show that a ligand specific for NOD1, a peptide derived from peptidoglycan, initiates an unexpected signaling pathway in human epithelial c...

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Auteurs principaux: Watanabe, Tomohiro, Asano, Naoki, Fichtner-Feigl, Stefan, Gorelick, Peter L., Tsuji, Yoshihisa, Matsumoto, Yuko, Chiba, Tsutomu, Fuss, Ivan J., Kitani, Atsushi, Strober, Warren
Format: Artigo
Langue:Inglês
Publié: American Society for Clinical Investigation 2010
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860924/
https://ncbi.nlm.nih.gov/pubmed/20389019
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI39481
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