Proteasomal degradation of retinoid X receptor α reprograms transcriptional activity of PPARγ in obese mice and humans

Obese patients have chronic, low-grade inflammation that predisposes to type 2 diabetes and results, in part, from dysregulated visceral white adipose tissue (WAT) functions. The specific signaling pathways underlying WAT dysregulation, however, remain unclear. Here we report that the PPARγ signalin...

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Autori principali: Lefebvre, Bruno, Benomar, Yacir, Guédin, Aurore, Langlois, Audrey, Hennuyer, Nathalie, Dumont, Julie, Bouchaert, Emmanuel, Dacquet, Catherine, Pénicaud, Luc, Casteilla, Louis, Pattou, Francois, Ktorza, Alain, Staels, Bart, Lefebvre, Philippe
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Clinical Investigation 2010
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Research Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860909/
https://ncbi.nlm.nih.gov/pubmed/20364085
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/JCI38606
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