Functional conservation of human Spastin in a Drosophila model of autosomal dominant-hereditary spastic paraplegia

Mutations in spastin are the most frequent cause of the neurodegenerative disease autosomal dominant-hereditary spastic paraplegia (AD-HSP). Drosophila melanogaster lacking spastin exhibit striking behavioral similarities to human patients suffering from AD-HSP, suggesting conservation of Spastin fu...

Descrición completa

Gardado en:
Detalles Bibliográficos
Main Authors: Du, Fang, Ozdowski, Emily F., Kotowski, Ingrid K., Marchuk, Douglas A., Sherwood, Nina Tang
Formato: Artigo
Idioma:Inglês
Publicado: Oxford University Press 2010
Assuntos:
Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860889/
https://ncbi.nlm.nih.gov/pubmed/20154342
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/hmg/ddq064
Tags: Engadir etiqueta
Sen Etiquetas, Sexa o primeiro en etiquetar este rexistro!

Títulos similares