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Examination of the expanding pathways for the regulation of p21 expression and activity
p21(Waf1/Cip1/Sdi1) was originally identified as an inhibitor of cyclin-dependent kinases, a mediator of p53 in growth suppression and a marker of cellular senescence. p21 is required for proper cell cycle progression and plays a role in cell death, DNA repair, senescence and aging, and induced plur...
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| Main Authors: | , , |
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| Format: | Artigo |
| Language: | Inglês |
| Published: |
2010
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| Subjects: | |
| Online Access: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2860671/ https://ncbi.nlm.nih.gov/pubmed/20100570 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.cellsig.2010.01.013 |
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