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Amitriptyline does not block the action of ATP at human P2X4 receptor

BACKGROUND AND PURPOSE: Amitriptyline is a tricyclic antidepressant that is also widely used to treat neuropathic pain in humans, but the mechanism of this anti-hyperalgesic effect is unknown. Microglia in the mouse spinal cord become activated in neuropathic pain, and expression of P2X4 receptors b...

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Detalhes bibliográficos
Main Authors: Sim, JA, North, RA
Formato: Artigo
Idioma:Inglês
Publicado em: Blackwell Publishing Ltd 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2860209/
https://ncbi.nlm.nih.gov/pubmed/20331601
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1476-5381.2010.00683.x
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