Upregulation of PTEN in Glioma Cells by Cord Blood Mesenchymal Stem Cells Inhibits Migration via Downregulation of the PI3K/Akt Pathway

BACKGROUND: PTEN (phosphatase and tensin homologue deleted on chromosome ten) is a tumor suppressor gene implicated in a wide variety of human cancers, including glioblastoma. PTEN is a major negative regulator of the PI3K/Akt signaling pathway. Most human gliomas show high levels of activated Akt,...

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Main Authors: Dasari, Venkata Ramesh, Kaur, Kiranpreet, Velpula, Kiran Kumar, Gujrati, Meena, Fassett, Daniel, Klopfenstein, Jeffrey D., Dinh, Dzung H., Rao, Jasti S.
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2010
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859936/
https://ncbi.nlm.nih.gov/pubmed/20436671
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010350
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