Effects of CYP2B6 G516T polymorphisms on plasma efavirenz and nevirapine levels when co-administered with rifampicin in HIV/TB co-infected Thai adults

BACKGROUND: Cytochrome P450 2B6 (CYP2B6) metabolizes efavirenz and nevirapine, the major core antiretroviral drugs for HIV in Thailand. Rifampicin, a critical component of tuberculosis (TB) therapy is a potent inducer of CYP enzyme activity. Polymorphisms of CYP2B6 and CYP3A4 are associated with alt...

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Detalhes bibliográficos
Main Authors: Uttayamakul, Sumonmal, Likanonsakul, Sirirat, Manosuthi, Weerawat, Wichukchinda, Nuanjun, Kalambaheti, Thareerat, Nakayama, Emi E, Shioda, Tatsuo, Khusmith, Srisin
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859392/
https://ncbi.nlm.nih.gov/pubmed/20338069
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1742-6405-7-8
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