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A genetically-encoded reporter of synaptic activity in vivo
To image synaptic activity within neural circuits, we have tethered the genetically-encoded calcium indicator (GECI) GCaMP2 to synaptic vesicles by fusion to synaptophysin. The resulting reporter, SyGCaMP2, detects the electrical activity of neurons with two advantages over existing cytoplasmic GECI...
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| Main Authors: | , , , |
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| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2009
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2859341/ https://ncbi.nlm.nih.gov/pubmed/19898484 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nmeth.1399 |
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