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Retinoblastoma and the Genetic Theory of Cancer: An Old Paradigm Trying to Survive to the Evidence

Retinoblastoma (Rb) is considered to represent the prototype of cancer linked to the sequential loss or inactivation of both alleles of a so-called “tumor suppressor gene”, the Rb1 gene. The pathogenetic mechanism behind this tumor was first hypothesized by Knudson in 1971 and further confirmed by o...

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Autores principales: Mastrangelo, Domenico, Hadjistilianou, Theodora, De Francesco, Sonia, Loré, Cosimo
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi Publishing Corporation 2009
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Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2859046/
https://ncbi.nlm.nih.gov/pubmed/20445799
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2009/301973
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