Identification of a Potential Pharmacological Sanctuary for HIV Type 1 in a Fraction of CD4(+) Primary Cells

We have identified a subset of HIV-susceptible CD4(+)CCR5(+) cells in human PBMCs that can efficiently exclude protease inhibitors (PI) due to high P-glycoprotein (P-gp) efflux activity. Phenotypically these cells are heterogeneous, include both T and non-T cells, and some display markers of memory...

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Detalhes bibliográficos
Main Authors: Valentin, Antonio, Morrow, Matthew, Poirier, Richard H., Aleman, Karen, Little, Richard, Yarchoan, Robert, Pavlakis, George N.
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc. 2010
Assuntos:
Virology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858927/
https://ncbi.nlm.nih.gov/pubmed/20059395
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/aid.2009.0044
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