FAM-MDR: A Flexible Family-Based Multifactor Dimensionality Reduction Technique to Detect Epistasis Using Related Individuals

We propose a novel multifactor dimensionality reduction method for epistasis detection in small or extended pedigrees, FAM-MDR. It combines features of the Genome-wide Rapid Association using Mixed Model And Regression approach (GRAMMAR) with Model-Based MDR (MB-MDR). We focus on continuous traits,...

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Main Authors: Cattaert, Tom, Urrea, Víctor, Naj, Adam C., De Lobel, Lizzy, De Wit, Vanessa, Fu, Mao, Mahachie John, Jestinah M., Shen, Haiqing, Calle, M. Luz, Ritchie, Marylyn D., Edwards, Todd L., Van Steen, Kristel
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858665/
https://ncbi.nlm.nih.gov/pubmed/20421984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010304
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