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The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model
Although NPM1 gene mutations leading to aberrant cytoplasmic expression of nucleophosmin (NPMc(+)) are the most frequent genetic lesions in acute myeloid leukemia, there is yet no experimental model demonstrating their oncogenicity in vivo. We report the generation and characterization of a transgen...
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| Main Authors: | , , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2858489/ https://ncbi.nlm.nih.gov/pubmed/19666870 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2009-03-208587 |
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