The NH(2)-terminal region of S. pyogenes M5 protein confers protection against degradation by proteases and enhances mucosal colonization of mice

BACKGROUND: The NH(2)-terminal sequence of the M protein from group A streptococci (GAS) defines the serotype of the organism and contains epitopes that evoke bactericidal antibodies. METHODS: To identify additional roles for this region of the M protein, we constructed a mutant of M5 GAS expressing...

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Hauptverfasser: Penfound, Thomas A., Ofek, Itzhak, Courtney, Harry S., Hasty, David L., Dale, James B.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2858045/
https://ncbi.nlm.nih.gov/pubmed/20367460
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1086/652005
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