Glucose Intolerance and Reduced Proliferation of Pancreatic β-Cells in Transgenic Pigs With Impaired Glucose-Dependent Insulinotropic Polypeptide Function

OBJECTIVE: The insulinotropic action of the incretin glucose-dependent insulinotropic polypeptide (GIP) is impaired in type 2 diabetes, while the effect of glucagon-like peptide-1 (GLP-1) is preserved. To evaluate the role of impaired GIP function in glucose homeostasis and development of the endocr...

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Autors principals: Renner, Simone, Fehlings, Christiane, Herbach, Nadja, Hofmann, Andreas, von Waldthausen, Dagmar C., Kessler, Barbara, Ulrichs, Karin, Chodnevskaja, Irina, Moskalenko, Vasiliy, Amselgruber, Werner, Göke, Burkhard, Pfeifer, Alexander, Wanke, Rüdiger, Wolf, Eckhard
Format: Artigo
Idioma:Inglês
Publicat: American Diabetes Association 2010
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Original Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857903/
https://ncbi.nlm.nih.gov/pubmed/20185813
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-0519
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