Accelerated Increase in Serum Interleukin-1 Receptor Antagonist Starts 6 Years Before Diagnosis of Type 2 Diabetes: Whitehall II Prospective Cohort Study

OBJECTIVE: Although interleukin-1 receptor antagonist (IL-1Ra) treatment is associated with improved β-cell function and glycemic control in patients with type 2 diabetes, its role in the development of type 2 diabetes remains unclear. We used repeated measurements to characterize IL-1Ra trajectorie...

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Main Authors: Carstensen, Maren, Herder, Christian, Kivimäki, Mika, Jokela, Markus, Roden, Michael, Shipley, Martin J., Witte, Daniel R., Brunner, Eric J., Tabák, Adam G.
Format: Artigo
Jezik:Inglês
Izdano: American Diabetes Association 2010
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Original Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857902/
https://ncbi.nlm.nih.gov/pubmed/20185814
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1199
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