Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction

OBJECTIVE: Peripheral insulin resistance is linked to an increase in reactive oxygen species (ROS), leading in part to the production of reactive lipid aldehydes that modify the side chains of protein amino acids in a reaction termed protein carbonylation. The primary enzymatic method for lipid alde...

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Hauptverfasser: Curtis, Jessica M., Grimsrud, Paul A., Wright, Wendy S., Xu, Xin, Foncea, Rocio E., Graham, David W., Brestoff, Jonathan R., Wiczer, Brian M., Ilkayeva, Olga, Cianflone, Katherine, Muoio, Deborah E., Arriaga, Edgar A., Bernlohr, David A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Diabetes Association 2010
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Original Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857893/
https://ncbi.nlm.nih.gov/pubmed/20150287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1105
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