Downregulation of Adipose Glutathione S-Transferase A4 Leads to Increased Protein Carbonylation, Oxidative Stress, and Mitochondrial Dysfunction

OBJECTIVE: Peripheral insulin resistance is linked to an increase in reactive oxygen species (ROS), leading in part to the production of reactive lipid aldehydes that modify the side chains of protein amino acids in a reaction termed protein carbonylation. The primary enzymatic method for lipid alde...

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書誌詳細
主要な著者: Curtis, Jessica M., Grimsrud, Paul A., Wright, Wendy S., Xu, Xin, Foncea, Rocio E., Graham, David W., Brestoff, Jonathan R., Wiczer, Brian M., Ilkayeva, Olga, Cianflone, Katherine, Muoio, Deborah E., Arriaga, Edgar A., Bernlohr, David A.
フォーマット: Artigo
言語:Inglês
出版事項: American Diabetes Association 2010
主題:
Original Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857893/
https://ncbi.nlm.nih.gov/pubmed/20150287
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2337/db09-1105
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