Malignant Precursor Cells Pre-Exist in Human Breast DCIS and Require Autophagy for Survival

BACKGROUND: While it is accepted that a majority of invasive breast cancer progresses from a ductal carcinoma in situ (DCIS) precursor stage, very little is known about the factors that promote survival of DCIS neoplastic cells within the hypoxic, nutrient deprived intraductal microenvironment. METH...

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Detalhes bibliográficos
Main Authors: Espina, Virginia, Mariani, Brian D., Gallagher, Rosa I., Tran, Khoa, Banks, Stacey, Wiedemann, Joy, Huryk, Heather, Mueller, Claudius, Adamo, Luana, Deng, Jianghong, Petricoin, Emanuel F., Pastore, Lucia, Zaman, Syed, Menezes, Geetha, Mize, James, Johal, Jasbir, Edmiston, Kirsten, Liotta, Lance A.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857649/
https://ncbi.nlm.nih.gov/pubmed/20421921
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0010240
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