Constitutive Activation of Smoothened Leads to Female Infertility and Altered Uterine Differentiation in the Mouse

Previous work has identified Indian hedgehog (Ihh) as a major mediator of progesterone signaling during embryo implantation. Ihh acts through its downstream effector smoothened (Smo) to activate the GLI family of transcription factors. In order to gain a better understanding of Ihh action during emb...

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Autors principals: Franco, Heather L., Lee, Kevin Y., Rubel, Cory A., Creighton, Chad J., White, Lisa D., Broaddus, Russell R., Lewis, Michael T., Lydon, John P., Jeong, Jae-Wook, DeMayo, Francesco J.
Format: Artigo
Idioma:Inglês
Publicat: Society for the Study of Reproduction, Inc. 2010
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857637/
https://ncbi.nlm.nih.gov/pubmed/20130264
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1095/biolreprod.109.081513
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