Recombinant Leishmania mexicana CRK3:CYCA has protein kinase activity in the absence of phosphorylation on the T-loop residue Thr178

The activity of cyclin dependent kinases (CDKs), which are key regulators of the eukaryotic cell cycle, is regulated through post-translational mechanisms, including binding of a cyclin and phosphorylation. Previously studies have shown that Leishmania mexicana CRK3 is an essential CDK that is a fun...

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Bibliographic Details
Main Authors: Gomes, Felipe C., Ali, Nahla Osman M., Brown, Elaine, Walker, Roderick G., Grant, Karen M., Mottram, Jeremy C.
Format: Artigo
Language:Inglês
Published: 2010
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Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857504/
https://ncbi.nlm.nih.gov/pubmed/20338198
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molbiopara.2010.03.002
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