A polycystin-2 (TRPP2) dimerization domain essential for the function of heteromeric polycystin complexes

Autosomal dominant polycystic kidney disease (ADPKD) is caused by mutations in two genes, PKD1 and PKD2, which encode polycystin-1 (PC1) and polycystin-2 (PC2), respectively. Earlier work has shown that PC1 and PC2 assemble into a polycystin complex implicated in kidney morphogenesis. PC2 also assem...

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Main Authors: Giamarchi, Aurélie, Feng, Shuang, Rodat-Despoix, Lise, Xu, Yaoxian, Bubenshchikova, Ekaterina, Newby, Linda J, Hao, Jizhe, Gaudioso, Christelle, Crest, Marcel, Lupas, Andrei N, Honoré, Eric, Williamson, Michael P, Obara, Tomoko, Ong, Albert CM, Delmas, Patrick
Format: Artigo
Language:Inglês
Published: Nature Publishing Group 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857461/
https://ncbi.nlm.nih.gov/pubmed/20168298
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2010.18
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