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R753Q Single Nucleotide Polymorphism Impairs Toll-like Receptor 2 Recognition of Hepatitis C Virus Core and Nonstructural 3 Proteins

BACKGROUND: Hepatitis C virus (HCV) core and nonstructural 3 (NS3) proteins induce inflammation and immunity through a Toll-like receptor 2 (TLR2)-dependent pathway. Individuals with the R753Q single nucleotide polymorphism (SNP) in the TLR2 gene have increased risk of allograft failure after liver...

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Bibliografiske detaljer
Main Authors: Brown, Robert A., Gralewski, Jonathon H., Eid, Albert J., Knoll, Bettina M., Finberg, Robert W., Razonable, Raymund R.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857328/
https://ncbi.nlm.nih.gov/pubmed/20090572
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e3181cbac18
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