Impact of additional chromosomal aberrations and BCR-ABL kinase domain mutations on the response to nilotinib in Philadelphia chromosome-positive chronic myeloid leukemia

BACKGROUND: Additional chromosomal aberrations in Philadelphia chromosome-positive chronic myeloid leukemia are non-random and strongly associated with disease progression, but their prognostic impact and effect on treatment response is not clear. Point mutations in the BCR-ABL kinase domain are pro...

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Hlavní autoři: Kim, Theo D., Türkmen, Seval, Schwarz, Michaela, Koca, Gökben, Nogai, Hendrik, Bommer, Christiane, Dörken, Bernd, Daniel, Peter, le Coutre, Philipp
Médium: Artigo
Jazyk:Inglês
Vydáno: Ferrata Storti Foundation 2010
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857187/
https://ncbi.nlm.nih.gov/pubmed/20015884
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2009.014712
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