Caspase-7 Cleavage of Kaposi Sarcoma-associated Herpesvirus ORF57 Confers a Cellular Function against Viral Lytic Gene Expression

Kaposi sarcoma-associated herpesvirus (KSHV) ORF57 is a viral early protein essential for KSHV multiplication. We found that B cells derived from cavity-based B cell lymphoma with lytic KSHV infection display activation of caspase-8 and cleavage of ORF57 in the cytoplasm by caspase-7 at the aspartat...

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Hlavní autoři: Majerciak, Vladimir, Kruhlak, Michael, Dagur, Pradeep K., McCoy, J. Philip, Zheng, Zhi-Ming
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Protein Synthesis and Degradation
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2857008/
https://ncbi.nlm.nih.gov/pubmed/20159985
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.068221
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