cAMP-stimulated Protein Phosphatase 2A Activity Associated with Muscle A Kinase-anchoring Protein (mAKAP) Signaling Complexes Inhibits the Phosphorylation and Activity of the cAMP-specific Phosphodiesterase PDE4D3

The concentration of the second messenger cAMP is tightly controlled in cells by the activity of phosphodiesterases. We have previously described how the protein kinase A-anchoring protein mAKAP serves as a scaffold for the cAMP-dependent protein kinase PKA and the cAMP-specific phosphodiesterase PD...

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Autores principales: Dodge-Kafka, Kimberly L., Bauman, Andrea, Mayer, Nicole, Henson, Edward, Heredia, Lorena, Ahn, Jung, McAvoy, Thomas, Nairn, Angus C., Kapiloff, Michael S.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2010
Materias:
Signal Transduction
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856983/
https://ncbi.nlm.nih.gov/pubmed/20106966
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.034868
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