The N Terminus of Monoamine Transporters Is a Lever Required for the Action of Amphetamines

The serotonin transporter (SERT) terminates neurotransmission by removing serotonin from the synaptic cleft. In addition, it is the site of action of antidepressants (which block the transporter) and of amphetamines (which induce substrate efflux). We explored the functional importance of the N term...

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Detalhes bibliográficos
Main Authors: Sucic, Sonja, Dallinger, Stefan, Zdrazil, Barbara, Weissensteiner, René, Jørgensen, Trine N., Holy, Marion, Kudlacek, Oliver, Seidel, Stefan, Cha, Joo Hwan, Gether, Ulrik, Newman, Amy H., Ecker, Gerhard F., Freissmuth, Michael, Sitte, Harald H.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2010
Assuntos:
Neurobiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2856298/
https://ncbi.nlm.nih.gov/pubmed/20118234
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.083154
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