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Deletion of M(1) Muscarinic Acetylcholine Receptors Increases Amyloid Pathology In Vitro and In Vivo

Alzheimer's disease (AD) is a progressive neurological disorder that causes dementia and poses a major public health crisis as the population ages. Aberrant processing of the amyloid precursor protein (APP) is strongly implicated as a proximal event in AD pathophysiology, but the neurochemical...

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Detalhes bibliográficos
Main Authors: Davis, Albert A., Fritz, Jason J., Wess, Jürgen, Lah, James J., Levey, Allan I.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855655/
https://ncbi.nlm.nih.gov/pubmed/20335454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.6393-09.2010
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