A Comprehensive Haplotype Analysis of the XPC Genomic Sequence Reveals a Cluster of Genetic Variants Associated with Sensitivity to Tobacco-Smoke Mutagens

The impact of single-nucleotide polymorphisms (SNPs) of the DNA repair gene XPC on DNA repair capacity (DRC) and genotoxicity has not been comprehensively determined. We constructed a comprehensive haplotype map encompassing all common XPC SNPs and evaluated the effect of Bayesian-inferred haplotype...

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Detalhes bibliográficos
Main Authors: Rondelli, Catherine M., El-Zein, Randa A., Wickliffe, Jeffrey K., Etzel, Carol J., Abdel-Rahman, Sherif Z.
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2010
Assuntos:
Genetic Toxicology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855352/
https://ncbi.nlm.nih.gov/pubmed/20106949
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/toxsci/kfq027
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