Prolonged Transgene Expression with Lentiviral Vectors in the Aqueous Humor Outflow Pathway of Nonhuman Primates

We injected lentiviral vectors into the eyes of live nonhuman primates to assess potential for glaucoma gene therapy. Anterior chambers of five cynomolgus monkeys were injected with green fluorescent protein (GFP)-encoding feline immunodeficiency viral vectors. The monkeys were monitored for in vivo...

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Bibliographic Details
Main Authors: Barraza, Román A., Rasmussen, Carol A., Loewen, Nils, Cameron, J. Douglas, Gabelt, B'Ann T., Teo, Wu-Lin, Kaufman, Paul L., Poeschla, Eric M.
Format: Artigo
Language:Inglês
Published: Mary Ann Liebert, Inc. 2009
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Scientific Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2855254/
https://ncbi.nlm.nih.gov/pubmed/19301472
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/hum.2008.086
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