Metformin Supplementation and Life Span in Fischer-344 Rats

Calorie restriction (CR) has been known for more than 70 years to extend life span and delay disease in rodent models. Metformin administration in rodent disease models has been shown to delay cancer incidence and progression, reduce cardiovascular disease and extend life span. To more directly test...

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Bibliographic Details
Main Authors: Smith, Daniel L., Elam, Calvin F., Mattison, Julie A., Lane, Mark A., Roth, George S., Ingram, Donald K., Allison, David B.
Format: Artigo
Language:Inglês
Published: Oxford University Press 2010
Subjects:
Journal of Gerontology: BIOLOGICAL SCIENCES
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854888/
https://ncbi.nlm.nih.gov/pubmed/20304770
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/gerona/glq033
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