UNCOUPLING THE COUPLED CALCIUM AND ZINC DYSHOMEOSTASIS IN CARDIAC MYOCYTES AND MITOCHONDRIA SEEN IN ALDOSTERONISM

Intracellular [Ca(2+)](i) overloading in cardiomyocytes is a fundamental pathogenic event associated with chronic aldosterone/salt treatment (ALDOST) and accounts for an induction of oxidative stress that leads to necrotic cell death and consequent myocardial scarring. This prooxidant response to Ca...

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Autors principals: Kamalov, German, Ahokas, Robert A., Zhao, Wenyuan, Zhao, Tieqiang, Shahbaz, Atta U., Johnson, Patti L., Bhattacharya, Syamal K., Sun, Yao, Gerling, Ivan C., Weber, Karl T.
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2854852/
https://ncbi.nlm.nih.gov/pubmed/20051880
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/FJC.0b013e3181cf0090
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