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Uncoupling JAK3 activation induces apoptosis in human lymphoid cancer cells via regulating critical survival pathways
In the current work, we report that specific inhibition of JAK3 via NC1153 induces apoptosis of certain leukemia/lymphoma cell lines. Affymetrix microarray profiling following NC1153 treatment unveiled JAK3 dependent survival modulating pathways (p53, TGF-β, TNFR and ER stress) in Kit225 cells. IL-2...
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| Autors principals: | , , , , , |
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| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2010
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2854231/ https://ncbi.nlm.nih.gov/pubmed/20211620 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.febslet.2010.02.071 |
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