17α-Estradiol arrests cell cycle progression at G2/M and induces apoptotic cell death in human acute leukemia Jurkat T cells

A pharmacological dose (2.5–10 μM) of 17α-estradiol (17α-E2) exerted a cytotoxic effect on human leukemias Jurkat T and U937 cells, which was not suppressed by the estrogen receptor (ER) antagonist ICI 182,780. Along with cytotoxicity in Jurkat T cells, several apoptotic events including mitochondri...

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Detalhes bibliográficos
Main Authors: Jun, Do Youn, Park, Hae Sun, Kim, Jun Seok, Kim, Jong Sik, Park, Wan, Song, Bang Ho, Kim, Hee-Sook, Taub, Dennis, Kim, Young Ho
Formato: Artigo
Idioma:Inglês
Publicado em: 2008
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853923/
https://ncbi.nlm.nih.gov/pubmed/18603276
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.taap.2008.05.023
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