Inhibition of AMPA receptor trafficking at hippocampal synapses by β-amyloid oligomers: the mitochondrial contribution

BACKGROUND: Synaptic defects represent a major mechanism underlying altered brain functions of patients suffering Alzheimer's disease (AD) [1-3]. An increasing body of work indicates that the oligomeric forms of β-amyloid (Aβ) molecules exert profound inhibition on synaptic functions and can ca...

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Main Authors: Rui, Yanfang, Gu, Jiaping, Yu, Kuai, Hartzell, H Criss, Zheng, James Q
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2010
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853530/
https://ncbi.nlm.nih.gov/pubmed/20346152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1756-6606-3-10
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