"Hypoxia-induced down-regulation of microRNA-449a/b impairs control over targeted SERPINE1 (PAI-1) mRNA - a mechanism involved in SERPINE1 (PAI-1) overexpression"

BACKGROUND: In damaged organs tissue repair and replacement of cells by connective tissue provokes a response of fibroblasts to cellular stress factors such as hypoxia. MicroRNAs (miRNA) are small non-coding RNA molecules which bind to their mRNA targets which eventually lead to repression of transl...

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Detalhes bibliográficos
Main Authors: Muth, Michaela, Theophile, Katharina, Hussein, Kais, Jacobi, Christoph, Kreipe, Hans, Bock, Oliver
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2010
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853517/
https://ncbi.nlm.nih.gov/pubmed/20356416
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-8-33
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