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Hypoxia-induced proliferation of human pulmonary microvascular endothelial cells depends on epidermal growth factor receptor tyrosine kinase activation

We hypothesized that hypoxia would activate epidermal growth factor receptor (EGFR) tyrosine kinase, leading to increased arginase expression and resulting in proliferation of human pulmonary microvascular endothelial cell (hPMVEC). To test this hypothesis, hPMVEC were incubated in normoxia (20% O(2...

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Detalhes bibliográficos
Main Authors: Toby, Inimary T., Chicoine, Louis G., Cui, Hongmei, Chen, Bernadette, Nelin, Leif D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Physiological Society 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853344/
https://ncbi.nlm.nih.gov/pubmed/20139181
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajplung.00122.2009
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