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Glycosylases and AP-cleaving enzymes as a general tool for probe-directed cleavage of ssDNA targets

The current arsenal of molecular tools for site-directed cleavage of single-stranded DNA (ssDNA) is limited. Here, we describe a method for targeted DNA cleavage that requires only the presence of an A nucleotide at the target position. The procedure involves hybridization of a complementary oligonu...

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Bibliografiska uppgifter
Huvudupphovsmän: Howell, W. Mathias, Grundberg, Ida, Faryna, Marta, Landegren, Ulf, Nilsson, Mats
Materialtyp: Artigo
Språk:Inglês
Publicerad: Oxford University Press 2010
Ämnen:
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853139/
https://ncbi.nlm.nih.gov/pubmed/20081204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1238
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