A truncated DNA-damage-signaling response is activated after DSB formation in the G1 phase of Saccharomyces cerevisiae

In Saccharomyces cerevisiae, the DNA damage response (DDR) is activated by the spatio-temporal colocalization of Mec1-Ddc2 kinase and the 9-1-1 clamp. In the absence of direct means to monitor Mec1 kinase activation in vivo, activation of the checkpoint kinase Rad53 has been taken as a proxy for DDR...

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Bibliographische Detailangaben
Hauptverfasser: Janke, Ryan, Herzberg, Kristina, Rolfsmeier, Michael, Mar, Jordan, Bashkirov, Vladimir I., Haghnazari, Edwin, Cantin, Greg, Yates, John R., Heyer, Wolf-Dietrich
Format: Artigo
Sprache:Inglês
Veröffentlicht: Oxford University Press 2010
Schlagworte:
Genome Integrity, Repair and Replication
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2853130/
https://ncbi.nlm.nih.gov/pubmed/20061370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkp1222
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